This paper critically analyses the hypothesis of the aetiological link between EDCs and trans identities from a scientific point of view, evincing its lack of evidence. It also problematizes the hypothesis by drawing from gender studies scholars who have denounced the transsex panic underlying the scientific literature on the effects of EDC on non-human animals, as well as from philosophical, biological, STG studies’, and neuroscientific elaborations that address sex-gender identities. It finds that the hypothesis that causally links prenatal exposure to EDCs and trans identities, which fuses biological determinism with a toxic and perturbing element, not only obscures the dynamic processual and relational character of trans identities, but also offers a pathologising understanding of them.