This study’s aim is to adapt the Health Care Communication Questionnaire in a Spanish sample, and then test the psychometric properties of the adapted instrument. To do so, the questionnaire was adapted for the Spanish context and then applied in a pilot study as well as a final study. The final sample consisted of 200 patients at Morales Meseguer Hospital in Murcia, Spain. The results show that this adaptation’s psychometric properties were similar to those of the original questionnaire. As for item analysis, all items obtained discriminant indices > .30. Confirmatory factor analysis revealed the same structure as that of the original questionnaire (χ2/df = 1.345; CFI = .983; IFI = .983; TLI = .977; RMSEA = .042), with indices reflecting adequate goodness of fit. Also, results from the analysis of each dimension’s internal consistency had coefficients between .71 and .86. We conclude that the Spanish version of the HCCQ has adequate psychometric properties, is useful, and will serve its purpose in the context in which it will be used.