Field studies were conducted during the 2003 through 2005 growing seasons to evaluate postemergence herbicides and timing of application for horse purslane, smellmelon, and Palmer amaranth control in peanut. Acifluorfen provided inconsistent control of the three weed species. Bentazon failed to control Palmer amaranth, horse purslane, and smellmelon (< 65%), whereas 2,4-DB controlled horse purslane and smellmelon less than 70%. Diclosulam applied early postemergence (EPOST) controlled Palmer amaranth at least 77% but horse purslane control varied from 27 to 73% when applied EPOST and was less than 50% with the late postemergence (LPOST) application. Diclosulam controlled smellmelon less than 65%. Imazethapyr and imazapic controlled Palmer amaranth and smellmelon at least 70% but controlled horse purslane less than 65%. Lactofen controlled Palmer amaranth and horse purslane at least 93% with the EPOST application but had inconsistent control (40 to 100%) when applied LPOST. Smellmelon control with lactofen was also inconsistent. Removal of weed interference with all herbicides except bentazon provided peanut yields greater than the nontreated check.