Many anthropologists have now adopted a relational view of the culture concept. Much research has shown that, far from being bounded or self-replicating, cultures emerge through interactions between social Others. These findings are particularly important to research on borderlands and peripheries, where communities routinely encounter wide-ranging social and political diversity. We present ceramic frequencies alongside petrographic analysis from the Late Woodland component at Esseneca (38OC20) to illustrate two main points: (1) pottery types previously understood as culture historical isolates co-occur in parts of Upstate South Carolina, and (2) potters collected clays from two main geologic formations near the site. This research shows that communities in the region traveled freely, crossing cultural boundaries while acquiring potting clays. We suggest that this level of interaction between disparate social groups laid the foundation for some aspects of Mississippianization in the region.