The spread of perennial weeds, such as foxtail barley, is a prime deterrent to adoption of no-till cereal production in the Northern Great Plains. In a 3-yr study, the isopropylamine salt of glyphosate at 0.56 kg ai/ha plus nonionic surfactant at 0.25% (v/v) did not control established perennial foxtail barley in early spring. However, adding ammonium sulfate at 2.8 kg/ha to glyphosate plus surfactant improved the effectiveness and year-to-year consistency of glyphosate for killing this weed. This spring treatment fits into no-till farm practice in the Northern Great Plains, providing no-till farmers with a defined strategy to manage this perennial bunch-grass weed.