In this paper, the class of periodic Ornstein-Uhlenbeck processes is defined. It is shown that periodic Ornstein-Uhlenbeck processes are stationary Markov random fields and the class of stationary distributions is characterized. In particular, any self-decomposable distribution is the stationary distribution of some periodic Ornstein-Uhlenbeck process. As examples, gamma periodic Ornstein-Uhlenbeck processes and Gaussian periodic Ornstein-Uhlenbeck processes are considered.