This chapter focuses on empirically supported interventions for common problems that may arise during clinical work with young children with medical problems. The reader will first be introduced to a review of the current research literature regarding prenatal and perinatal medical concerns, with specific emphasis on assessing prenatal psychiatric symptoms and subsequent interventions following these assessments during this early time. This section is then followed by an emphasis on interventions for young children that focus on helping with procedural anxiety associated with routine medical interventions, including resources for assistance with pill swallowing and information about pediatric medical traumatic stress that can occur during hospitalizations and/or as a result of injuries. At the end of the chapter, emphasis is placed on common feeding and toileting concerns that may arise in young children, as well as general guidelines and strategies for intervention. Resources are provided to help clinicians assess prenatal and perinatal medical concerns, utilize reward charts to help promote toileting, and provide sample social stories for children to help them prepare for a visit to the hospital; resources for pediatric medical traumatic stress are also provided.