This study was conducted to evaluate the tolerance of two black bean cultivars, AC Harblack and Midnight Black Turtle, to preplant incorporated (PPI) and preemergence (PRE) applications of S-metolachlor at 1.6 and 3.2 kg ai/ha, imazethapyr at 0.075 and 0.15 kg ai/ha, and S-metolachlor plus imazethapyr at 1.6 plus 0.075 and 3.2 plus 0.15 kg ai/ha, respectively, at Exeter and Ridgetown, Ontario, Canada, in 2001 and 2002. There were generally no differences between the two cultivars in their responses to the herbicide treatments. PPI and PRE applications of S-metolachlor did not reduce black bean growth or yield. The PPI and PRE applications of imazethapyr alone or in tank mixture with S-metolachlor at the low and high rates did not have a significant effect on plant height, dry weight, seed moisture content, or yield at Ridgetown but caused as much as 14% visual crop injury at Exeter and reduced plant height, dry weight, and yield as much as 25, 40, and 49%, respectively. The higher rate of either herbicide alone or in tank mixture generally caused greater crop injury than the lower rate. At sites where there was a significant difference, the PPI application caused less crop injury than the PRE application. On the basis of these results, the PPI and PRE applications of S-metolachlor can be applied safely at the recommended label rate for the control of annual grass in black beans. However, the PPI and the PRE applications of imazethapyr alone and in tank mixture with S-metolachlor require careful application to avoid spray overlaps because there is potential for crop injury and yield reduction under some environmental conditions.