This study is the first to characterize and provide an account of serum parameters in a wild population of female sobaity sea-bream Sparidentex hasta during the spawning season. The average concentrations of aspartate aminotransferase, alanine aminotransferase (ALT) and lactate dehydrogenize (LDH) were: 220.2 ± 17.50, 9.4 ± 2.44 and 1745 ± 259.81 U/L respectively. The ALT concentration correlated positively with cholesterol and triglycerides (P < 0.01), and LDH correlated positively with ALT. Cholesterol and triglycerides had a positive correlation with liver enzymes (P < 0.01). Average glucose concentration was 130.8 ± 11.15 and ranged between 114 and 155 mg/dl. E2 ranged between 14.36 and 27.32 Pg/ml in the spawning season and was positively correlated with length and weight (P < 0.01).