In recent decades, the proliferation of single-use plastic products has significantly contributed to a surge in plastic pollution on a global scale. Researchers have extensively investigated the impacts of plastic pollution across various regions, yet a comprehensive holistic and location-based understanding of these impacts in the West African context is lacking. This study addresses this gap through a systemic assessment of the impacts of plastic pollution, in West Africa, particularly Ghana. Employing a qualitative system dynamics causal modelling approach, this study establishes linkages between pollution effects at the macro level, constructing a hierarchical outline of both high- and low-level impacts. The significance of this research lies in the application of pertinent systems thinking techniques to comprehend the broader impacts of plastic pollution. The outcomes of this study will inform the development of effective policies aimed at preventing or mitigating plastic pollution in Ghana, and potentially the wider West African context.