Search

Only show content I have access to (0)

Chapters (1)

Over 3 years (1)

From year:

To year:

Apply

Medicine (1)

Cambridge University Press (1)

1 results

Chapter 7 - Fetal and neonatal alloimmune thrombocytopenia
from Section 2 - Fetal disease
- By Khadija Madani, Dick Oepkes
Edited by Mark D. Kilby, Anthony Johnson, Baylor College of Medicine, Texas, Dick Oepkes
Book:

Fetal Therapy

Published online:

05 February 2013

Print publication:

13 December 2012, pp 67-77
- Chapter
- - Get access
    
    Check if you have access via personal or institutional login
    
    Log in Register
- Export citation
Summary

This chapter focuses on fetal and neonatal alloimmune thrombocytopenia (FNAIT), which is one of the major causes of both severe thrombocytopenia and intracranial hemorrhage (ICH) in fetuses and term neonates. FNAIT is caused by maternal immunization against human platelet antigens (HPAs) on fetal platelets, inherited from the father and different from those present in the mother. The chapter also focuses on the current insights in the etiology, diagnosis, and management of pregnancies at known risk of FNAIT. The diagnosis of FNAIT is unequivocal when paternal incompatibility with corresponding maternal alloantibodies is present. The primary goal of the management of a neonate with FNAIT is to prevent or stop thrombocytopenic bleeding. In suspected cases of FNAIT, babies with severe thrombocytopenia can be transfused with random platelets transfusions, until the diagnosis is established and matched platelets are available.