This paper explores gender mainstreaming in the context of health policy and health variations between women and men. Despite the adoption of gender mainstreaming at international, regional and national scales since the Beijing Platform for Action in 1995, gender inequalities in health persist. The paper argues that the translation of gender mainstreaming as a global policy paradigm across and between policy scales has significance for health policies aiming to address gender. The paper suggests that while gender mainstreaming originated to address women's needs, the paradigm is founded on goals that do not translate in health policy; that the representation of the problem of gender in this global paradigm is problematic in a health context; and that the role of global networks in policy translation as part of this paradigm has led to the replacement of transformative ideals with technocratic solutions which shift the focus away from gender relations of power.