Skip to main content Accessibility help

We use cookies to distinguish you from other users and to provide you with a better experience on our websites. Close this message to accept cookies or find out how to manage your cookie settings.

Close cookie message
×
  1. Home
  2. Search

Refine search

Refine search

Access:
Content type:
Publication date:
Apply   From and To filters
Subject: Show more
Journals Show more
Publishers: Show more
Societies Show more
Series: Show more
Collections: Show more

Actions for selected content:

Select all | Deselect all
  • View selected items
  • Export citations
  • Download PDF (zip)
  • Save to Kindle
  • Save to Dropbox
  • Save to Google Drive

Save Search

You can save your searches here and later view and run them again in "My saved searches".

Please provide a title, maximum of 40 characters.
Cancel
×

2 results

  • 14 - Pre-implantation genetic testing

  • from SECTION 2 - THE EMBRYO
  • Edited by Hilary Critchley, University of Edinburgh, Iain Cameron, University of Southampton, Stephen Smith
  • Book:
    Implantation and Early Development
    Published online:
    05 June 2014
    Print publication:
    01 June 2005, pp 169-182

  • Summary

    Pre-implantation genetic testing (PGT) can be classified as either pre-implantation genetic diagnosis (PGD) or pre-implantation genetic screening (PGS). PGS aims to improve the outcome of assisted reproductive technology (ART) treatment for the subfertile by testing for a number of the more frequent chromosome aneuploidies in an attempt to improve implantation and reduce the incidence of miscarriage. The first successful clinical application of PGD, to avoid the X-linked condition adrenoleukodystrophy, used polymerase chain reaction (PCR) to amplify a specific repeat on the Y chromosome in order to sex embryos. Patients performing embryo biopsy must be approved and licensed by the Human Fertilisation and Embryology Authority (HFEA) after inspection. The use of PGD for the prevention of transmission of serious genetic disease has largely been overtaken in volume by use of embryo biopsy to improve in vitro fertilisation (IVF) outcome for subfertile couples.