I outline a general thermodynamic condition for the earliest steps in the origin of life based on fluctuation theorems developed in the last two decades. I argue that the exponentially developing loop of asymmetric autocatalysis and thermodynamic tail-wind condition (TTC) in the prebiotic clutter was a key to a particular trajectory of decluttering via a sequence of early symmetry breaking events. Such decluttering was bound to result, most prominently, in homochiral amino acids and homochiral sugars composing nucleotides as the TTC exponentially favoured asymmetric autocatalytic processes over catalytic and symmetric autocatalytic processes in the clutter. I describe the loop's structure, including its chemical and physical properties, and explain that the TTC/asymmetric autocatalysis loop intersected with multiple chemical, geological and climatological feedback loops, thus providing conditions for the propagation of living systems as we know them.
