Producers in the central Great Plains are seeking alternative strategies to manage weeds because of herbicide resistance, narrow profit margins, and a lack of registered herbicides in some crops. Thus, we evaluated the impact of cultural systems in winter wheat and tillage on weed dynamics in corn, sunflower, and proso millet planted the year following wheat harvest. Weed seedling densities were 25 to 30% lower in a no-till system compared with minimum-till with a sweep plow. With no-till, cultural systems that produced more crop residue reduced weed densities an additional 15 to 30%, compared with the conventional system. Cultural system effect was eliminated in dry years and by tillage. Weed biomass was 10-fold less in proso millet than in corn. Crop residue management, critical for successful cropping in semiarid regions, also will help weed management by reducing weed density in summer annual crops, especially in no-till systems.