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2 results

  • 11 - Substance-Related and Addictive Disorders

  • Kenneth Carter, Emory University, Atlanta
  • Book:
    Psychopathology
    Published online:
    22 December 2022
    Print publication:
    22 December 2022, pp 338-377

  • Summary

    Describes the categories of psychoactive drugs. Describes the effects of psychoactive drugs on the nervous system. Identifies diagnostic symptoms associated with intoxication, withdrawal, and substance use disorders. Lists the various models and treatments for substance use disorders.

  • Chapter 9 - Pain therapeutics

  • Edited by James E. Barrett, Joseph T. Coyle, Michael Williams
  • Book:
    Translational Neuroscience
    Published online:
    05 July 2012
    Print publication:
    28 June 2012, pp 168-177

  • Summary

    The identification of drugs to treat major psychiatric disorders launched the fields of biological psychiatry, behavioral pharmacology, and neuropsychopharmacology. It had a profound impact not only on individuals suffering from these disorders and on the care and hospitalization of patients but also on the emergence of entirely new disciplines. The astute observations in the clinical setting that led to the first generation of psychoactive drugs created the putative framework for the potential discovery of new generations of psychotropic agents. The key challenge in the search for a new generation of improved psychoactive drugs has focused on: enhanced validation of the animal models used to characterize new chemical entities (NCEs) as bona fide models of the human disease and the use of these models to effectively translate NCEs to the human disease state. The learning curve for CNS research focuses on the unique complexity of the brain.