While invalid voting is often treated as protest behavior in an electoral context, its association with actual political protests has not yet been empirically demonstrated. The relative scarcity of research on the topic is likely due to the hybrid nature of invalid voting as a both formal and informal political gesture. The novel availability of event-based data for public protests in Latin America allows for testing whether their occurrence is connected with changes in spoiled and blank ballots. Using an appropriate dynamic regression model covering variations in the 148 intervals between Latin American legislative elections in the 1979–2021 period, this study finds a strong connection between the emergence of antigovernment protests and surges in invalid voting (and vice versa). This relationship still holds at parity of economic conditions and it is reinforced by a lack of alternation in the party of power. Conversely, the appearance of workers’ strikes appears to work as a substitute for this behavior, which is also chosen by voters when democracy deteriorates, while corruption has no independent impact on invalid voting. Overall this work’s findings promise to send the research agenda on invalid voting in a new direction, previously unexplored because of an absence of fitting data.