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  • 9 - Pharmacodynamic principles and mechanisms of drug interactions

  • from Part III - Pharmacodynamic interactions
    • By Blaise F. D. Bourgeois, Harvard Medical School, Division of Epilepsy and Clinical Neurophysiology, Children's Hospital, Boston, MA, USA
  • Edited by Jerzy Majkowski, Blaise F. D. Bourgeois, Harvard University, Massachusetts, Philip N. Patsalos, Institute of Neurology, London, Richard H. Mattson, Yale University, Connecticut
  • Book:
    Antiepileptic Drugs
    Published online:
    07 September 2009
    Print publication:
    26 May 2005, pp 181-192

  • Summary

    Pharmacodynamic interactions consist of the quantitative or qualitative alterations of any effect of a drug on any organ when these alterations are caused by the presence of another drug in the body. In order for two drugs to have a pharmacodynamic interaction, they have to share at least one common pharmacodynamic property or they have to share an identifiable clinical effect. Whenever a patient takes two or more medications simultaneously, there is the potential for some type of pharmacodynamic interaction. There can be doubt that one of the main disadvantages of antiepileptic combination therapy is an increase in the intensity or number of side effects. This chapter discusses the clinical significance of pharmacodynamic interactions and their advantages and disadvantages. A literature review of data in animals and in humans was used to determine whether appropriate antiepileptic drugs (AED) combinations can be selected on the basis of their mechanism of action.