We investigate the global asymptotic stability for positive solutions to a class of general symmetric rational difference equations and prove that the unique positive equilibrium 1 of the general symmetric rational difference equations is globally asymptotically stable. As a special case of our result, we solve the conjecture raised by Berenhaut, Foley and Stević [‘The global attractivity of the rational difference equation yn=(yn−k+yn−m)/(1+yn−kyn−m)’, Appl. Math. Lett.20 (2007), 54–58].