Brittle reactivation of plastic shear zones is frequently observed in geologically old terranes. To better understand such deformation zones, we have studied the >700 Ma long structural history of the Himdalen–Ørje Deformation Zone (HØDZ) in SE Norway by K–Ar and 40Ar–39Ar geochronology, and structural characterization. Several generations of mylonites make up the ductile part of HØDZ, the Ørje Shear Zone. A 40Ar–39Ar white mica plateau age of 908.6 ± 7.0 Ma constrains the timing of extensional reactivation of the Ørje mylonite. The mylonite is extensively reworked during brittle deformation events by the Himdalen Fault. 40Ar–39Ar plateau ages of 375.0 ± 22.7 Ma and 351.7 ± 4.4 Ma from pseudotachylite veins and K–Ar ages of authigenic illite in fault gouge at c. 380 Ma are interpreted to date initial brittle deformation, possibly associated with the Variscan orogeny. Major brittle deformation during the Early–Mid Permian Oslo Rift is documented by a 40Ar–39Ar pseudotachylite plateau age of 294.6 ± 5.2 Ma and a K–Ar fault gouge age of c. 270 Ma. The last datable faulting event is constrained by the finest size fraction in three separate gouges at c. 200 Ma. The study demonstrates that multiple geologically significant K–Ar ages can be constrained from fault gouges within the same fault core by combining careful field sampling, structural characterization, detailed mineralogy and illite crystallinity analysis. We suggest that initial localization of brittle strain along plastic shear zones is controlled by mechanical anisotropy of parallel-oriented, throughgoing phyllosilicate-rich foliation planes within the mylonitic fabric.

The reactivation of dormant alpha-human herpesvirus (αHHV) has been attributed to various causes often referred to as stressors. However, no clinical study investigating the relationship between stressors and reactivation exists in humans at this time. Herpes simplex virus type-1 (HSV-1), an important αHHV, was shown to have its gene expression and replication regulated by thyroid hormone (TH) using molecular biology approaches. Varicella zoster virus (VZV) is categorized in αHHV superfamily and shares similar homology with HSV-1. We hypothesize that a history of TH imbalance may be associated with the incidence of shingles (VZV reactivation). This current pilot study, based on a hospital medical claims database, was conducted as a retrospective case-controlled investigation to determine if a putative link between TH imbalance and incidence of shingles is present. An odds ratio of 2·95 with a χ2 value of 51·74 was calculated for the total population diagnosed with TH disruption and shingles. Further analyses indicated that African American males exhibited a much higher chance of simultaneous diagnoses. These results show that a TH imbalance history may affect VZV reactivation at different incidence rates in different races and age groups.

The Palaeozoic rocks of the Dingle Peninsula provide a record of the evolution of the Caledonides, Acadides and Variscides. The succession ranges from Early Ordovician deep-water sediments, through Silurian shallow marine to non-marine sediments and volcanic rocks to an Old Red Sandstone (ORS) succession topped by Carboniferous marine shales. Comparison of structural styles in the unconformity-bounded groups, together with a detailed analysis of fault zones, allows the tectonic history to be deduced. The older rocks record Caledonian processes on the margin of Avalonia during Early Ordovician time and convergence then soft collision with Laurentia during Silurian time. The Dingle Basin was developed during the late Silurian – Early Devonian transtension in the Iapetus suture zone and was inverted in the latest Emsian Acadian orogenic episode. Post-Dingle Group ORS groups in the north of the peninsula were deposited in a syn-rift footwall block to the main Munster Basin. The Acadian transpressional and Munster Basin extensional structures were reactivated or overprinted in the Variscan deformation such that Acadian folds are transected by Variscan cleavage in both plan and vertical views. After Iapetus closure, changes in the tectonic regime are believed to be a result of adjustments in the geometry of subduction of the Rheic Ocean.

New detailed mapping and related field studies, together with re-assessment of prior investigations, have revealed that three groups of faults, orientated broadly NE, N and NW, have been the primary controls on stratigraphical, structural and geomorphological evolution in the upper Firth of Clyde since their initiation by proto-Variscan stresses in Late Devonian time. Extended control has been achieved through repeated episodic reactivation, during which existing lines of fracture were rejuvenated and others of similar orientation initiated. Movements on two (if not all three) groups of faults persisted until middle Palaeogene time at least. The faults have been augmented by two sets of irregularly distributed, open, plunging folds, broadly N–S and E–W in their axial orientations. Some N–S folds may be attributed to oblique or strike-slip movement on reactivated caledonoid faults, others to intermittent transpression, probably in Namurian–Westphalian times, affecting mainly the northeastern Midland Valley but stretching beyond the massif of the Clyde Lava Plateau to register a weakened presence as far W as the upper Firth. The N–S folds and dextral strike-slip movements on some faults may be far-field expressions of the Uralian Orogeny, whereas earlier, sinistral displacements on NE faults and the development of small, later and less-significant E–W folds may be related to different phases of long-lived Variscan compression from the S.

Endogenous transplacental transmission (EnTT) of Neospora caninum is the most common route of infection in cattle and occurs as a consequence of a reactivation of N. caninum infection that may lead to abortion or to the birth of congenitally infected calves. The reactivation of N. caninum infection was studied during the gestation of chronically infected dams and, for the first time, in their congenitally infected pups. BALB/c mice were infected with Nc-Spain 7 (Group 1) or Nc-Spain 3H (Group 2), high virulence isolates and low-to-moderate virulence isolates, respectively. The mice were mated after 90 days post-infection, and the morbidity, mortality, vertical transmission and humoral immune responses were recorded for 2 consecutive generations. In the first generation, higher morbidity and mortality rates were observed in G1 before mating than in G2 (P < 0·0001). In the second generation, low vertical transmission rates were observed in both inoculated groups (7·7% and 17·1% in G1 and G2, respectively) and were significantly diminished in the third generation (8·7% in G2 versus 0% in G1). Low rates of reactivation of N. caninum infection were induced in chronically infected mice and decreased in subsequent generations regardless of the isolate employed in the inoculations. Thus, further studies are needed to improve this reactivation mouse model.

The factors responsible for the reactivation of a Neospora caninum latent infection are unknown, but it is postulated that the maternal immune response could be altered during pregnancy. The immune response was investigated in N. caninum chronically infected mice during successive pregnancies as well as in non-pregnant infected mice and mice infected when pregnant. Vertical transmission was demonstrated in chronically infected mice after the first pregnancy but the rate of fœtal infection fell after further pregnancies. Non-pregnant chronically infected mice showed a marked specific proliferative response and an IgG2a isotype preferential secretion. During the course of the first pregnancy, no significant modification of the immune response was recorded. After 2 successive pregnancies, the specific cellular response showed a significant fall whereas Th2 cytokine mRNA expression was noted. At the same time, IgG1 secretion increased to reach the IgG2a level. At the third delivery, a partial restoration of the proliferative response was observed. The reactivation of N. caninum chronic infection during pregnancy does not seem to be consecutive to an immunodepression. Nevertheless, pregnancy could favour parasite multiplication in utero after an occasional spontaneous release of bradyzoites.

Herpes simplex virus type 1 (HSV-1) and type 2 (HSV-2) are ubiquitous human pathogens. They share with other herpesviruses the ability to establish lifelong latent infection of the host. Periodic reactivation from latency is responsible for most of the clinical disease burden of HSV infection. This review focuses on what we have learned from molecular studies in model systems of HSV latency, and the implications these findings have for treating recurrent HSV disease.

The Outer Hebrides Fault Zone is a major ESE-dipping detachment exposed within basement gneisses of the Archaean–Palaeoproterozoic Lewisian Complex, northwest Scotland. The fault zone exhibits a long-lived displacement history and was active during Proterozoic, end-Silurian, Carboniferous and Mesozoic times. The earliest deformation event preserved onshore was associated with top-to-the-NW ductile thrusting. A previous study proposed that thrust-related protomylonitic and mylonitic fabrics are cross-cut by amphibolites (‘Younger Basics’) and Laxfordian granite and pegmatite sheets. This evidence was used to suggest that ductile thrusting occurred during the Palaeoproterozoic Inverian event at c. 2500 Ma. Our observations demonstrate, however, that mylonitic fabrics within the ductile thrust zone are superimposed on all components of the gneiss complex including amphibolites and Laxfordian intrusions. It therefore follows that the Outer Hebrides Fault Zone cannot be older than c. 1685 Ma, the age of recently dated Laxfordian granites in the Outer Hebrides. Geochronological studies have shown that the basement blocks of the northern Outer Hebrides and Scottish mainland have different geological histories and were amalgamated during Proterozoic times at or after c. 1700 Ma. We propose that early ductile thrusting along the Outer Hebrides Fault Zone formed part of this amalgamation process leading to burial and reheating of the footwall gneisses in Lewis and north Harris. This would account for the c. 1100 Ma thermal event recorded by previous workers and implies that ductile thrusting along the Outer Hebrides Fault Zone is of Grenvillian age.