Society’s most well-intended efforts to solve sustainability challenges have not yet achieved the expected gains due to rebound effects (i.e., negative consequences of interventions arising from induced changes in system behaviour). Rebound effects offset about 40% of potential sustainability gains, but the understanding of design as a key leverage point for preventing rebound effects is still untapped. In this position paper, three fundamental scientific gaps hampering the prevention of rebound effects are discussed: (1) limited knowledge about the rebound effects triggered by efficiency–effectiveness–sufficiency strategies; (2) the influence of the counterintuitive behaviour of complex socio-technical systems in giving rise to rebound effects is not yet understood and (3) the bounded rationality within design limits the understanding of rebound effects at a broader systemic level. To address the aforementioned gaps, novel methodologies, simulation models and strategies to enable the design of reboundless interventions (i.e., products, product/service-systems and socio-technical systems that are resilient to rebound effects) are required. Building on the strong foundation of systems and design theory, this position paper argues for the need to bridge the interdisciplinary gap in the interplay of design and rebound effects, qualitative and quantitative models, engineering and social sciences, and theory and practice.