Three applications/yr of glyphosate [N-(phosphonomethyl)glycine] with a ropewick applicator (RWA), a roller applicator (RA), and a recirculating sprayer (RCS) were compared to hoeing and cultivation for the control of johnsongrass [Sorghum halepense (L.) Pers. ♯3 SORHA] in cotton (Gossypium hirsutum L. ‘Acala SJ-2′) in six field experiments from 1979 to 1981. Averaged over the 3 yr and dates of application, plots treated with glyphosate contained 78% fewer live johnsongrass shoots (15/m2) than cultivated-control plots (68/m2). Although applications of glyphosate with the RWA and RA improved or tended to improve yields of cotton, only plots treated with the RWA yielded significantly more seed cotton than cultivated control plots in all years. However, yields of plots treated with the RWA still averaged 38% less than hoed plots. Plots treated with the RA produced significantly more cotton than cultivated-control plots only in 1981.