This article presents three new annual indices of industrial output for Andalusia, Catalonia and the Basque Country between 1830 and 1975. The comparative analysis, the first to include the Basque Country, allows to specify the main tendencies of growth and structural change in the regions studied, two of them pioneers of the Spanish industrialization, Andalusia clearly left behind. The analysis highlights as well the changes operated in the composition of their respective industrial products and, with them, the different regional paths, going from specialization to the manufacturing diversification, followed during the 19th and 20th centuries.