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repressor

Protein Science (1)

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NikR is a ribbon-helix-helix DNA-binding protein
PETER T. CHIVERS, ROBERT T. SAUER
Journal:

Protein Science / Volume 8 / Issue 11 / November 1999

Published online by Cambridge University Press:

01 November 1999, pp. 2494-2500

Print publication:

November 1999
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Escherichia coli NikR, a repressor with homologs in other bacteria and archaea, was identified as a potential new member of the ribbon-helix-helix (β-α-α) family of transcription factors in profile based sequence searches and in structure prediction experiments. Biophysical and biochemical characterization of the N-terminal domain of NikR show that it has many features expected of a β-α-α protein including α-helical content, dimeric solution form, concentration dependent thermal stability, and ability to bind DNA in sequence-specific manner. Mutation of a residue predicted to be important for DNA-binding reduces operator affinity but does not affect the secondary structure or stability of the protein.