Movement ecology and environmental factors are topics of paramount importance to consider when planning conservation programmes for target species. Here we discuss this topic by reviewing the available information related to the Egyptian Vulture Neophron percnopterus, with reference to the remnant breeding population of Southern Italy, of high conservation concern and subject of a long-term captive-breeding re-stocking programme. We describe how adverse wind conditions over the Central Mediterranean Sea make the sea-crossing challenging with detrimental effects on the survival of inexperienced birds, and coupled this information with count data of migrating Egyptian Vultures. Furthermore, we indicate how low population size and scarce opportunities in meeting migrating conspecifics could potentially lead juvenile Egyptian Vultures to follow unfavourable migratory routes, with possible repercussions on survival. We postulate how these concomitant factors could be indirectly influencing the long-term survival of this small population, principally affected by anthropogenic threats. We also discuss how the same factors could actually be affecting captive-bred young individuals released in late summer in southern continental Italy, in the framework of the restocking programme. An integrative approach with tailor-made release methods, which also takes into account the age of released birds and geographical and environmental factors, would likely be useful for a more goal-oriented and long-lasting conservation outcome, for the preservation of this endangered scavenger.