Earthquakes are considered as one of the most destructive disasters. Several theories exist that attempt to explain earthquake behavior. The concept accepted by seismologists is the Tectonics Plate Theory. The persistent threat of seismic events and the difficulties involved with mitigating their effects highlight the importance of disaster preparedness. A review of pertinent literature reveals that up to 20% of the patients hospitalized after earthquakes suffer from nontrauma-related conditions. The conditions commonly seen are acute exacerbations of chronic conditions such as diabetes, chronic obstructive pulmonary disease, acute coronary syndromes and myocardial infarctions, end-stage renal disease, anxiety, hypertension, and the onset of spontaneous abortions, among others. Although investigators examining the medical consequences of seismic events have made significant progress, additional work is necessary to further improve the care and outcomes of earthquake victims. These endeavors require a true transdisciplinary approach involving participation by individuals from multiple medical, health, and nonmedical specialties.