Heritability of susceptibility to infection with Theileria parva was estimated from full sib families of Rhipicephalus appendiculatus ticks. Male and female ticks of 2 stocks were mated singly. Nineteen full sib families of the Muguga stock and 17 full sib families of the Kiambu stock were obtained. Nymphae of these families were fed on cattle infected with T. parva so that the ticks became replete on days 16 and 17 after infection when the blood was parasitaemic with intraerythrocytic piroplasms. The T. parva infections were assessed in the resultant adult ticks of each full sib group and the abundance of infection, the number of salivary gland acini infected/tick, was found to be the most useful parameter for analysis. Estimates of heritability of the susceptibility to infection with T. parva for the Kiambu and the Muguga tick stocks were 0·24 and 0·26 respectively. Using only the data from ticks which fed on day 16, the heritability estimates were 0·39 for the Kiambu stock and 0·59 for the Muguga stock. These results indicate that tick lines of high or low susceptibility for T. parva infection could be produced through selection.

The sensitivity to dietary lysine: energy content of pigs from lines divergently selected over seven generations for components of efficient lean growth rate was quantified by the within-selection line regression of performance test traits on diet class. Large White pigs were performance tested over three 14-day test-periods starting at 30, 50 and 75 kg and offered, to appetite, isoenergetic diets differing in dietary total lysine: energy (0•59, 0•69, 0•81, 0•91, 1•01, 1•12 and 1•23 g/MJ digestible energy (DE)). Within each litter, full-sibs were performance tested on different diets. Pigs were also performance tested on a diet-choice procedure using diets with total lysine: energy of 0•69 and 1•12 g/MJ DE to determine the correlation between performance on phase-feeding and diet-choice.

The study consisted of 578 animals with 459 pigs tested with phase-feeding and 119 tested on diet-choice procedures. The study detected significant selection line and dietary effects on performance test traits, but no significant between-selection line differences in sensitivity to dietary total lysine: energy. When combinations of performance test traits were transformed into predicted lysine and energy utilization traits there were significant selection line effects on predicted nutrient allocation, but not in responses to increasing dietary total lysine: energy. The lack of between-selection line differences in sensitivity to dietary total lysine: energy indicated that the consequences of changing dietary total lysine: energy will be broadly similar across a range of genotypes, as spanned by the selection lines of the study.

Genetic correlations between performance traits of phase-fed and diet-choice pigs suggested that predictions of genetic merit will be similar with animals tested on either procedure between 30 and 75 kg but post 75 kg predicted genetic merit for growth rate and lysine intake should be estimated separately for performance on diet-choice or for performance on a given diet. In contrast, predicted genetic merit for fat deposition with performance testing on diet-choice will be highly correlated with predicted genetic merit with testing on a single diet.

Using deterministic methods, rates of genetic gain (Δ G) and inbreeding (Δ F) were compared between pure line selection (PLS) and combined crossbred purebred selection (CCPS), for the sire line of a three-way crossbreeding scheme. Purebred performance and crossbred performance were treated as genetically correlated traits assuming the infinitesimal model. Breeding schemes were compared at a fixed total number of purebred selection candidates, i.e. including crossbred information did not affect the size of the purebred nucleus. Selection was by truncation on estimated breeding values for crossbred performance. Rates of genetic gain were predicted using a pseudo-BLUP selection index. Rates of inbreeding were predicted using recently developed methods based on long-term genetic contributions. Results showed that changing from PLS to CCPS may increase ΔF by a factor of 2·14. In particular with high heritabilities and low purebred-crossbred genetic correlations, CCPS requires a larger number of parents than PLS, to avoid excessive ΔF. The superiority of CCPS over PLS was judged by comparing ΔG from both selection strategies at the same ΔF. At the same ΔF, CCPS was superior to PLS and the superiority of CCPS was only moderately reduced compared with the situation without a restriction on ΔF. This paper shows that the longterm genetic contribution theory can be used to balance ΔF and ΔG in animal breeding schemes within very limited computing time.

Inbreeding leads to reduction of the additive variance, whereas inbreeding depression reduces the performance of milk producing cows in both the nucleus and the commercial population. In this study, the cumulative additive response to 30 years of selection corrected for variance reduction due to inbreeding and inbreeding depression in the commercial cow population (denoted as expected phenotypic level or P) was evaluated in a closed (1024 cows tested per year) dairy cattle nucleus scheme, assuming a large number of gametes available per female. No dominance effects were simulated nor estimated in the nucleus. Various hierarchical and factorial designs with fewer sires than dams, an equal number of sires and dams, or even a larger number of sires than dams were compared for P. The trait considered was overall economic merit for milk production with a heritability of the unselected base population of 0·30. Sires and dams were selected on their animal model estimated additive effect for the trait considered at either 15 or 27 months of age. All full-sibs were available for selection. In the absence of inbreeding depression, a complete factorial scheme with more sires than dams resulted in the highest P. With increasing inbreeding depression, the optimal number of sires increased relatively more than the optimal number of dams. Increasing the number of sires decreased inbreeding relatively more than increasing the number of dams, and resulted in a relatively higher P. This is due to the fact that correlations between estimated additive effects of male selection candidates are higher than between those of female selection candidates.