Globally, semi-arid lands (SALs) are home to approximately one billion people, including some of the poorest and least food secure. These regions will be among the hardest hit by the impacts of climate change. This article urges governments and their development partners to put SAL inhabitants and their activities at the heart of efforts to support adaptation and climate resilient development, identifying opportunities to capitalize on the knowledge, institutions, resources and practices of SAL populations in adaptation action.