The review explores key issues associated with discrimination and hostility faced by Lesbian, Gay, Bisexual and Transgender (LGBT) people at work and organizational responses to it. Starting from a description of the main challenges facing LGBT workers’ identity management, the review examines manifestations of negative attitudes towards gender and sexual minority groups, highlighting processes of subtle discrimination and exclusion. It presents and critiques dominant organizational responses to LGBT stigmatization, highlighting the need for holistic, intersectional approaches, and pointing out issues requiring further research.