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1 results

  • Congenital Malformations Associated With a Single Umbilical Artery in Twin Pregnancies

  • Sarah E. Mitchell, Karen Reidy, Fabricio Da Silva Costa, Ricardo Palma-Dias, Thomas J. Cade, Mark P. Umstad
  • Journal:
    Twin Research and Human Genetics / Volume 18 / Issue 5 / October 2015
    Published online by Cambridge University Press:
    20 August 2015, pp. 595-600
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  • A single umbilical artery (SUA) was identified in 1.5% of twin pregnancies. The presence of a SUA in a twin pregnancy was associated with a 50% incidence of fetal anomalies, many of them complex and severe. The embryology and pathophysiological mechanisms associated with a SUA are reviewed. Aneuploidy is relatively common and should be considered, particularly in the presence of associated anomalies. Fetal growth restriction is frequent and preterm delivery is common.