During the twentieth century, deaths from infectious diseases have declined dramatically around the world, particularly in industrialized countries. Injury prevention strategies have long existed; however, only relatively recently have these interventions been based on firm scientific evidence and rigorous evaluation. It is the evidence-based approach to advances in injury control that holds the most promise in further reducing the impact of injury on our society. One of the most important milestones in the development of injury research was the publication of Accident Research: Methods and Approaches by Haddon et al. in 1964. Research into violence-related injury has been predominantly conducted by criminologists, psychologists, and sociologists. Injury research must incorporate the scientific advances as it searches for etiologic mechanisms of injury, tests new interventions, especially those based on new technology and laboratory discoveries, and examines the impact of interventions on patient outcomes.