The Cambridge Neuropsychological Testing Automated Battery (CANTAB) is useful for the evaluation of frontal and temporal lobe dysfunction in adults with acquired lesions. The primary measures of frontal lobe function within the CANTAB battery task are spatial working memory, a self-guided search task; the Tower of London, a test of planning and behavioral inhibition; and the intradimensional/extradimensional set-shifting task, which measures the ability to shift cognitive response sets both within and across categories. CANTAB measures temporal lobe recognition memory functions through delayed-match-to-sample (DMTS) recognition memory tasks. Three other CANTAB tasks such as motor screening task, spatial span task and pattern recognition are treated as controls for the frontal lobe-mediated behavioral functions that are of primary interest. This chapter talks about the clinical validation of CANTAB in children with neurologic disorders and strategies for validation of CANTAB in childhood assessment.