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  • Chapter 31 - Spermatogonial Stem Cell Culture and the Future of Germline Gene Editing

  • from Section 4 - Laboratory Evaluation and Treatment of Male Infertility
  • Edited by Douglas T. Carrell, Utah Center for Reproductive Medicine, Alexander W. Pastuszak, University of Utah, James M. Hotaling, Utah Center for Reproductive Medicine
  • Book:
    Men's Reproductive and Sexual Health Throughout the Lifespan
    Published online:
    06 December 2023
    Print publication:
    16 November 2023, pp 244-250

  • Summary

    Human spermatogonial stem cells (hSSCs), the only type of germline stem cells in adult men, are responsible to ensure lifetime-long sperm production in men after sex maturation. As the starting point of spermatogenesis, this cell type delicately balances its self-renewal and differentiation, which is essential for spermatogenesis to proceed continuously. A deep and systematic understanding of hSSCs is critical for treating testis-related pathology such as male infertility and testicular germ cell tumor. In this chapter, we provide a systematic review of our previous and current understanding of hSSCs, as well as the advancement of ex vivo systems to culture human germline. Ultimately, the successful establishment of an hSSC-based human germline culture system will not only greatly benefit the study of human germ cell biology by serving as a useful platform, but also provide potential therapeutic options to treat male infertility and preserve fertility for childhood cancer patients.