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The L6 membrane proteins—A new four-transmembrane superfamily
MARK D. WRIGHT, JIAN NI, GEORGE B. RUDY
Journal:

Protein Science / Volume 9 / Issue 8 / August 2000

Published online by Cambridge University Press:

01 August 2000, pp. 1594-1600

Print publication:

August 2000
- Article
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L6, IL-TMP, and TM4SF5 are cell surface proteins predicted to have four transmembrane domains. Previous sequence analysis led to their assignment as members of the tetraspanin superfamily. In this paper, we identify a new sequence (L6D) that is strikingly similar to L6, IL-TMP, and TM4SF5. Analyses of these four sequences indicate that they are not significantly related to genuine tetraspanins, but instead constitute their own L6 superfamily.