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2 results

  • Dual Antiplatelet Therapy in Minor Stroke/Transient Ischemic Attack – An Updated Network Meta-Analysis

  • Ronda Lun, Gabriele Zitikyte, Danielle Carole Roy, Shan Dhaliwal, Dar Dowlatshahi
  • Journal:
    Canadian Journal of Neurological Sciences / Volume 51 / Issue 4 / July 2024
    Published online by Cambridge University Press:
    11 September 2023, pp. 577-580
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  • We previously analyzed five trials on ticagrelor/aspirin versus clopidogrel/aspirin in patients with minor stroke/ TIA in a network meta-analysis. We updated our search and identified 311 new citations with one study for inclusion: CHANCE2 enrolled patients with CYP2C19 loss-of-function alleles and randomized them to ticagrelor/aspirin or clopidogrel/aspirin. Pooling of CHANCE2 with the original studies could not be completed due to violation of NMA assumptions, due to significant inconsistency. This suggests patients with CYP2C19 loss-of-function alleles represent a subpopulation that is inherently different from the general stroke population in their antiplatelet response. Results from CHANCE-2 may not be generalizable without genotype testing.