Search

Skip to main content Accessibility help

Home
Search

Only show content I have access to (0)

Chapters (1)

Last 3 years (1)

From year:

To year:

Apply

Medicine (1)

topical analgesics

Cambridge University Press (1)

View selected items
Save to my bookmarks
Export citations
Download PDF (zip)
Save to Kindle
Save to Dropbox
Save to Google Drive
Save content to
To save content items to your account, please confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your account. Find out more about saving content to .

To save content items to your Kindle, first ensure no-reply@cambridge.org is added to your Approved Personal Document E-mail List under your Personal Document Settings on the Manage Your Content and Devices page of your Amazon account. Then enter the ‘name’ part of your Kindle email address below. Find out more about saving to your Kindle.

Note you can select to save to either the @free.kindle.com or @kindle.com variations. ‘@free.kindle.com’ emails are free but can only be saved to your device when it is connected to wi-fi. ‘@kindle.com’ emails can be delivered even when you are not connected to wi-fi, but note that service fees apply.

Find out more about the Kindle Personal Document Service.

Please be advised that item(s) you selected are not available.
You are about to save
Your Kindle email address

Please provide your Kindle email.

@free.kindle.com @kindle.com (service fees apply)

By using this service, you agree that you will only keep content for personal use, and will not openly distribute them via Dropbox, Google Drive or other file sharing services

1 results

Chapter 6 - Topicals
from Part II - Common Categories of Pharmacologic Medications to Treat Chronic Pain
- By Juyeon Kakazu, Elyse M. Cornett
Edited by Omar Viswanath, Creighton University, Omaha, Ivan Urits, Southcoast Brain & Spine Center, Wareham
Book:

Cambridge Handbook of Pain Medicine

Published online:

01 December 2023

Print publication:

14 December 2023, pp 49-52
- Chapter
- - Get access
    
    Check if you have access via personal or institutional login
    
    Log in Register
- Export citation
Summary

Oral medication has been the mainstay of therapy; however, the use of topical formulation for chronic pain can reduce serious systemic side effects caused by oral medications. Topical administration of medication via patches, gels, creams, ointments, and solutions can provide local anesthesia and bypass major organ system. Lidocaine is an amide-type local anesthetic agent stabilizing the neuronal membranes by inhibiting the ionic fluxes required for initiation and conduction of impulses. Capsaicin is a selective agonist for TRPV1 receptor expressed in afferent neuronal C fibers and Ad fibers resulting in loss of receptor functionality causing impaired local nociception.Diclofenac works via inhibition of prostaglandin synthesis by blocking COX-1 and COX-2.