In this article we present a study that seeks to explain the nature of, and the mortuary practices behind, the burials containing multiple individuals at the site of El Caño, Panama (part of the “Gran Coclé” archaeological tradition, ca. AD 700–1000). We set out to test our first impression of these burials as products of sumptuous funerals held upon the death of the rulers that included, among other practices, human sacrifice. With this in mind, our research aims to elucidate the status relationships between individuals, the circumstances of their deaths, and the religious and symbolic significance of their burials. The results reveal the presence of an individual of higher status within every tomb, the existence of a pattern with respect to the status of those who accompany that individual, the practice of mortuary treatments typical of sacrificial contexts, toxic substances, an iconography referring to human sacrifice, and the clear intention of using a burial as a representation of social order. Considering all this, we conclude that multiple burials at this site should be interpreted as high status. Our study highlights the practice of human sacrifice in funerary rituals linked to that status.