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1 results

  • 18 - Techniques of molecular genetics

  • from Part 5 - Future directions
  • Edited by Monique Ernst, National Institutes of Health, Baltimore, Judith M. Rumsey, National Institute of Mental Health, Bethesda, Maryland
  • Foreword by Joseph T. Coyle
  • Book:
    Functional Neuroimaging in Child Psychiatry
    Published online:
    06 January 2010
    Print publication:
    12 October 2000, pp 315-327

  • Summary

    This chapter describes the techniques that facilitate new understanding of neuroimaging results by adding a molecular genetic approach to examining neuroimaging phenotypes. It provides Mendelian genetics to highlight the point that variation in a single gene can affect many of the phenotypes measured in neuroimaging. The chapter discusses the expansion of trinucleotide repeat DNA sequences and imprinting, to the characteristics the inheritance and course of a disorder. The genetic analysis of pairs of siblings examines the degree of similarity between affected siblings for a quantitative phenotype. The transmission disequilibrium test (TDT) is based on the fact that a parent donates a single chromosome of each pair and, thus, one allele of any particular genetic marker. The population association method is commonly used but has a serious caveat, which is the association test between two groups of unrelated individuals.