Gastrointestinal distress is a common symptom of anxiety. While these symptoms are usually transient and not severe, in some cases they can cause significant impairment. This report details the treatment of a 45-year-old male who presented with symptoms of diarrhoea and vomiting which occurred every time he travelled more than 10 miles away from his home. These symptoms arose suddenly and without warning, and on at least two occasions the vomiting was so severe that it caused the patient to vomit blood. Due to this problem, the patient had developed agoraphobia which had affected his life for over 15 years. The patient was treated in 14 sessions which involved educating him about gastrointestinal reactivity and having him perform a series of emotional tolerance, opposite-action, and real-life exposure exercises. After receiving treatment, the patient embarked on a series of vacations and business trips, all without experiencing diarrhoea or vomiting, and a follow-up assessment showed that the treatment gains were maintained 1 year later.
