Globally, water resources are under immense and increasing pressure. This, coupled with the threat of climate change, has increased global interest in water reuse. However, global water reuse remains limited because of public opposition. This paper thus examines public perceptions and attitudes to water reuse across the world. It finds that results from studies of water reuse acceptance have tended to be context specific, although claims can be made about the universal relevance of some predictors, underscoring the need for individual water reuse schemes to carefully consider their local context. Disgust remains a constant in the public psyche, while public trust in delivery agents as well as how water reuse is communicated vis-à-vis perceptions about the quality and safety of recycled water are also critical. The latter particularly highlights public concerns about the indeterminate health risks associated with water reuse.