Soft red winter wheat response to the herbicides AE F130060 00 plus AE F115008 00 applied alone or with the safener AE F107892 at the three-leaf, two-tiller, and six-tiller growth stages was determined in a field experiment in North Carolina. AE F130060 00 at 25 g ai/ha plus AE F115008 00 at 5 g ai/ha, twice the anticipated use rate, applied with safener injured wheat 9% but did not affect grain yield, grain test weight, number of spikes, number of kernels per spike, or kernel weight. Results were similar with safener at herbicide–safener ratios of 1:1 and 1:3 regardless of the wheat growth stage at application. Without the safener, AE F130060 00 plus AE F115008 00 applied at the three-leaf, two-tiller, and six-tiller growth stages injured wheat an average of 27% and reduced grain yields 5, 5, and 11%, respectively. Yield losses were attributed to reduced numbers of kernels per spike. AE F130060 00 at 12.5 g/ha plus AE F115008 00 at 2.5 g/ha plus AE F107892 at 15 g ai/ha did not affect grain yield or yield components.