The effectiveness of single and repeated annual preharvest glyphosate applications (1 to 2 wk before crop harvest) to reduce Canada thistle populations was evaluated in field experiments near Bezanson, AB, Scott, SK, and St. Albert, AB. Single applications of glyphosate at 0.45 to 1.8 kg/ha at Bezanson and St. Albert reduced Canada thistle shoot density by more than 75% but in the three experiments at Scott 1.8 kg/ha was required to consistently obtain a similar reduction. Four consecutive, annual applications of glyphosate at 0.45 kg/ha or more did not eliminate Canada thistle but reduced shoot densities by more than 98% at Bezanson. At Scott, similar reductions occurred in two of three sites following two consecutive, annual preharvest applications of glyphosate at the same rates. In the third Scott site the 1.8 kg/ha rate of glyphosate provided a similar reduction but lower rates did not. At Bezanson, barley yields following the first, second, and third applications of glyphosate at 0.45 kg/ha or more were 14% greater than check plots where MCPA was applied in the spring. Yields of wheat seeded 1 yr after a single application of glyphosate at St. Albert were 26% greater than from unsprayed checks. Barley yields seeded 1 yr after each glyphosate application at Scott were not affected because Canada thistle populations were sparse.