The Makira Natural Park (Makira) is the largest terrestrial protected area in Madagascar, supporting nearly 200,000 people living around the park, who derive a significant proportion of their animal-source foods from hunting. Makira is currently managed with three different policies: (1) traditional management with no external assistance; (2) community-based forest management (Gestion Contractualisée des Forêts; GCF) with non-governmental support and externally developed policies; and (3) strict external management policies (Zone d’Occupation Controlée; ZOC), meaning a zone of controlled residence for communities inside the core protected area. Here, we longitudinally assess the impacts of these policies on wildlife hunting and consumption by using a difference-in-differences method to evaluate policy efficacy. We found that externally developed conservation policies led to drastically reduced wildlife hunting and consumption in Makira. We also found that public education in the form of environmental awareness-raising, conducted 1 year before adoption, led to a greater concealment of hunting behaviours. Overall, wildlife hunting and consumption have decreased in the Makira region since the adoption of GCF and ZOC policies and could be effective at reducing the unsustainable wildlife hunting across the Makira, particularly when supported by economic development and the creation of alternative sources of livelihood and food.