This article looks at the specific early modern trade practice of the pacotille and at pacotille commercial networks, particularly of free women of colour, as a means of approaching female trade knowledge and intimate networks in the ancien régime Caribbean colonies. Surviving documentation of this flexible commerce allows us to approach women of highly different backgrounds as knowledgeable and skilled agents within the socioeconomic framework of eighteenth-century global trade, who combined their knowledge of the male-dominated trading spheres with their own intimate networks in highly profitable ways. This essay explores not only what these women knew about long-distance trade, but also how they used their local expertise (e.g., of time regimes, landscape, and people) as well as their intimate networks for personal gain in the eighteenth-century French colonial worlds.