The present study’s objective is to create a Spanish adaptation of the Conditions of Work Effectiveness Questionnaire II (CWEQ-II) by Laschinger, Finegan, Shamian, and Wilk (2004) in order to measure structural empowerment in an organizational context. To do so, this study was conducted in two distinct phases. In the first, a group of experts carried out a back-translation of the questionnaire and in the second phase, we analyzed the questionnaire’s internal structure (through exploratory and confirmatory factor analysis) and external validity. The resulting Spanish version of the questionnaire (CWEQ-S) demonstrated/exhibited good factor structure and good psychometric properties as far as reliability and validity are concerned.