This article analyzes several patterns of antisemitism in twentieth-century Latin America. It identifies historical moments when carriers of social and political ideas projected negative images of Jews, sometimes pushing anti-Jewish policies and at times leading violent actions against Jews. Thus, antisemitism served to mobilize in defense of national identity; as a reaction to Jewish peddlers perceived as a threat to national economies; as a basis for the generalized rejection of “undesirable refugees” during World War II and the Holocaust; and as a Cold War phenomenon, along with anticommunism and neo-Nazism. Like other forms of xenophobia, antisemitism was grounded in prejudice and the demonization of a supposed enemy rather than being based on verified evidence. Analysis suggests that antisemitism has been deeply rooted in Latin America and has manifested over time with changing historical and social constellations. At the same time, while Judeophobic prejudices and actions have been intimidating and have at times precluded the legal immigration of Jews, antisemitism has rarely become dominant or led to systemic social discrimination, massive expulsion, or mass genocide, unlike in Europe.