Greenhouse studies were conducted to determine purple and yellow nutsedge response to selective placement of a 5-cm layer of pyrithiobac sodium-treated soil above, below, or above and below nutsedge tubers. Pyrithiobac sodium at 36 or 72 g ae ha−1 applied postemergence as foliar, soil, or foliar and soil treatments also was evaluated. Pyrithiobac sodium applied above, below, or above and below nutsedge tubers reduced yellow and purple nutsedge shoot number, shoot regrowth, and root-tuber dry weight at least 90%. Foliar-only treatment of pyrithiobac sodium was less effective at reducing emerged purple and yellow nutsedge numbers than application to soil only or to foliage and soil. Best reduction in yellow and purple nutsedge growth with pyrithiobac sodium was obtained with soil-incorporated treatments.