Field experiments were conducted at five sites in Nebraska in 2000 and 2001 to determine the effect of planting depth and isoxaflutole rate on the response of an isoxaflutole-sensitive corn hybrid, ‘Pioneer 33-G’ across variable environments. Corn was planted at depths of 2.5 and 5.0 cm, and isoxaflutole was applied PRE at the recommended (1×) and twice the recommended (2×) rate. The effects of planting depth and herbicide rate on injury varied considerably across site–years. When injury was evident, it was generally greater at the high rate of isoxaflutole (2×) and at the shallow planting depth (2.5 cm). In most site–years, corn recovered from early season injury, and yields were not reduced, except at Scottsbluff, NE, and North Platte, NE, where soils were lower in organic matter and higher in pH. Isoxaflutole rates should be carefully selected for soils with low organic matter and high pH.