We use cookies to distinguish you from other users and to provide you with a better experience on our websites. Close this message to accept cookies or find out how to manage your cookie settings.
We use cookies to distinguish you from other users and to provide you with a better experience on our websites. Close this message to accept cookies or find out how to manage your cookie settings.
Yes
from Section III - Ovarian Cancer
Published online by Cambridge University Press: 20 July 2023
Recurrence rates and mortality in women with advanced ovarian cancer remain high, despite progress in therapeutic strategies and surgical techniques in the last decades. Peritoneal dissemination is a distinctive feature in the natural history of the disease and forms a target for hyperthermic intraperitoneal chemotherapy (HIPEC), complementary to (near) complete cytoreductive surgery (CRS). The high intraperitoneal concentration of chemotherapy under hyperthermic conditions increases penetration into tumor deposits and potentiates the cytotoxic effect. A recent randomized controlled trial demonstrated its evident survival benefit in front-line in a selected patient population, without incurring additional toxicity. Whether this survival benefit applies to women undergoing primary CRS is currently investigated. Several unanswered questions – e.g. open versus closed procedure, patient selection, and integration with subsequent therapies – need more research, ultimately leading to a uniform protocol and adoption into routine care, with the aim of improving survival outcomes for women with advanced ovarian cancer.
To save this book to your Kindle, first ensure no-reply@cambridge.org is added to your Approved Personal Document E-mail List under your Personal Document Settings on the Manage Your Content and Devices page of your Amazon account. Then enter the ‘name’ part of your Kindle email address below. Find out more about saving to your Kindle.
Note you can select to save to either the @free.kindle.com or @kindle.com variations. ‘@free.kindle.com’ emails are free but can only be saved to your device when it is connected to wi-fi. ‘@kindle.com’ emails can be delivered even when you are not connected to wi-fi, but note that service fees apply.
Find out more about the Kindle Personal Document Service.
To save content items to your account, please confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your account. Find out more about saving content to Dropbox.
To save content items to your account, please confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your account. Find out more about saving content to Google Drive.
