We use cookies to distinguish you from other users and to provide you with a better experience on our websites. Close this message to accept cookies or find out how to manage your cookie settings.
We use cookies to distinguish you from other users and to provide you with a better experience on our websites. Close this message to accept cookies or find out how to manage your cookie settings.
PARP Inhibitor
from Section III - Ovarian Cancer
Published online by Cambridge University Press: 20 July 2023
The integrated genomic analysis of high-grade serous ovarian cancer carried out by The Cancer Genome Atlas Research Network (TCGA) identified two large subgroups of patients, those harboring homologous recombination (HR) deficiency (50%), characterized by genetic and epigenetic alterations of HR genes, most commonly the BRCA1 and BRCA2 genes, and those with an intact HR pathway, enriched in Cyclin E1 (CCNE1) amplifications. These HR-proficient tumors are associated with inferior survival outcomes and poorer response to PARP inhibitors (PARPi), in comparison with HR-deficient tumors [1,2].
Currently, two of the most used commercially available assays to test HR-deficiency status, Myriad myChoice CDx and the Foundation Medicine’s FoundationFocus CDx, are challenged by the reliable identification of HR-proficient tumors.
To save this book to your Kindle, first ensure no-reply@cambridge.org is added to your Approved Personal Document E-mail List under your Personal Document Settings on the Manage Your Content and Devices page of your Amazon account. Then enter the ‘name’ part of your Kindle email address below. Find out more about saving to your Kindle.
Note you can select to save to either the @free.kindle.com or @kindle.com variations. ‘@free.kindle.com’ emails are free but can only be saved to your device when it is connected to wi-fi. ‘@kindle.com’ emails can be delivered even when you are not connected to wi-fi, but note that service fees apply.
Find out more about the Kindle Personal Document Service.
To save content items to your account, please confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your account. Find out more about saving content to Dropbox.
To save content items to your account, please confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your account. Find out more about saving content to Google Drive.
